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SilkInk™ is a bioink, designed to specifically mimic the 3D tissue environment of bone marrow for 3D bioprinting and culturing human hematopoietic stem and progenitor cells (HSPCs) and bone marrow cells. This bioink enables the 3D bioprinting of in vitro models of hematopoiesis in customizable shapes and volumes.
Users can mix the bioink directly with their cells of interest and 3D bioprint at the desired scale and structure. The process occurs at 37°C using a heated printhead. After printing, cross-linking stabilizes the 3D structure, forming a stable, soft 3D matrix that supports long-term culture and differentiation in culture. Standard cell culture media can be used.
Its transparency, optical clarity, and structural uniformity allow for direct live imaging, confocal microscopy, and multimodal microscopy assays.
Cells can also be retrieved using our Dissolving Solution for cytometry, biochemical and molecular assays.
SilkInk™ offers superior mechanical strength, cell-adhesive properties, and long-term stability compared to alginate or gelatin especially for bone marrow cells.
Supporting blood-cell research, uncovering disease mechanisms, and advancing drug development.
Hematopoiesis Research: By recreating key features of the bone marrow niche, SilkInkTM enables detailed investigation of normal blood cell development, allowing researchers to study the regulation, dynamics, and interactions that drive physiological hematopoiesis in a controlled environment.
Disease Modeling: By recreating the bone marrow niche, SilkInkTM facilitates the study of hematological disorders, allowing researchers to investigate disease mechanisms and progression in a controlled environment.
Drug Screening and Development: The bioink's compatibility with patient-derived cells enables ex vivo testing of therapeutics.
Bioprinting Soft 3D Models of Hematopoiesis using Natural Silk Fibroin-Based Bioink Efficiently Supports Platelet Differentiation
Adv Sci (Weinh). 2024 May;11(18):e2308276.
doi: 10.1002/advs.202308276
Newly identified roles for PIEZO1 mechanosensor in controlling normal megakaryocyte development and in primary myelofibrosis
Am J Hematol. 2024 Mar;99(3):336-349.
doi: 10.1002/ajh.27184